Zürcher Nachrichten - Moderna mRNA mpox vaccine shows promise in animal study

It comes amid an outbreak of the disease in Africa -- partly driven by a new variant that emerged in the Democratic Republic of Congo -- which has been declared an international emergency.

Senior author and virologist Jay Hooper from the US Army Medical Research Institute for Infectious Diseases told AFP that researchers were interested in exploring mRNA technology to find a "sweet spot" -- an mpox vaccine that is both highly safe and highly effective.

Vaccines for mpox, previously known as monkeypox, were originally developed to combat smallpox, which has since been eradicated.

The currently licensed JYNNEOS vaccine uses a "live attenuated" virus, meaning the virus has been weakened so it cannot cause disease in humans.

That attenuation also limits its protective efficacy compared to the older ACAM2000 vaccine -- which was however potentially infectious.

In contrast, the mRNA vaccine includes genetic instructions that train the host's immune system to recognize four key viral antigens, which are crucial for the virus to attach to cells.

Moderna uses the same mRNA technology in its highly safe and effective coronavirus vaccine.

In the study, six macaques were vaccinated with the mRNA vaccine, and another six received an equivalent of the currently licensed vaccine.

Eight weeks after their initial dose, all 12 vaccinated macaques were exposed to a lethal strain of mpox. A third group of six unvaccinated macaques was also exposed to the virus.

Researchers monitored the health of the animals over a four-week period, taking blood samples to assess their immune responses.

As anticipated, all vaccinated animals survived, regardless of the vaccine type, while five out of the six unvaccinated animals died.

"But if we focus specifically on the outcomes with the mRNA vaccine, what we saw was quite surprising and exciting," co-senior author Galit Alter, a virologist and immunologist at Moderna, told AFP.

Animals that received the mRNA vaccine experienced less weight loss and developed significantly fewer lesions compared to those given the live attenuated vaccine.

On average, the control group developed up to 1,448 lesions, the group vaccinated with the older vaccine had a maximum of 607 lesions, and the mRNA-vaccinated group had only 54 lesions at most.

Moreover, the mRNA vaccine shortened the period during which the animals exhibited lesions by more than 10 days compared to the MVA vaccine. It also resulted in lower viral loads in both blood and throat swabs, suggesting it could be more effective in reducing transmission.

First author Alec Freyn of Moderna told AFP that serum from the mRNA-vaccinated macaques was also tested against other viruses in the Orthopox family, and it effectively neutralized vaccinia, cowpox, rabbitpox, camelpox, and ectromelia virus.

The vaccine candidate, named mRNA-1769, is now being tested in an early-stage human clinical trial in the UK to assess its safety and immune response.

P.E.Steiner--NZN